Literature Review

DHPS

EVOLUTION OF THE DHPS GENE

DHPS is highly conserved in plants and eukaryotes, which means that it plays an important role in cell function. In humans, the gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19. Read More.

NON-HUMAN DHPS MODELS

Non-human DHPS models include Neurospora crassa, Leishmania donovani, T. brucei, and bovine DHPS. Read More.

DHPS SYNTHESIS REACTION

DHPS gene encodes for a DHPS protein which catalyzes a reversible reaction that transfers the 4-aminobutyl functional group from spermidine to the amino group of Lys329 of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Read More.

ASSAYS

These assays are methods developed for quantifying the amount and activity of DHPS. Read More.

NAD DEPENDENT ENZYME BINDING

Spermadine-enzyme binding is dependent on NAD and the maximum binding for NAD and spermidine is 4 molecules/enzyme tetramer. Read More.

ACTIVATION

Phosphorylation of DHPS is CK2-dependent and PKC-mediated. Iron binding is required for DHPS formation. Read More.

INHIBITORS

Inhibitors of DHPS include: GC7, Guanylhydrazone CNI-1493, and AXD455. Read More.

DHPS FUNCTION

DHPS plays a vital role in RNA processing, protein synthesis, and cell growth. Read More.

EIF5A

eIF5A interacts in a hypusine-dependent manner with a molecular complex and plays an important role in translation of mRNA to protein.  Read More.

CANCER AND CENTRAL NERVOUS SYSTEM

DHPS is of particular interest in cancer and in the central nervous system, as it is upregulated in cancers due to its involvement in cell proliferation. Read More.

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