Literature Review

DHPS



DHPS Function

DHPS plays a vital role in RNA processing, protein synthesis, and cell growth.

  • Functional significance of eIF5A and its hypusine modification in eukaryotes. (PMID: 19997760,(ncbi.nlm.nih.gov)) Park M.H. … Valentini S.R. Amino Acids 2010 3 64
    • This study describes how different gene disruption and mutation studies provided information on the essential nature of eIF5A and the deoxyhypusine/hypusine modification in cell growth and in protein synthesis.
  • Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax. (PMID: 17042947,(ncbi.nlm.nih.gov)) Njuguna J.T. … Kaiser A.E. BMC Microbiol. 2006 22 64
    • This study describes the identity of a novel DHPS protein in P. vivax, characterized using specific enzymatic activity, cross-reactivity with a polyclonal antibody against human DHPS, and amino acid identity with DHPS homologs.
  • Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467,(ncbi.nlm.nih.gov)) Park J.-H. … Park M.H. Proc. Natl. Acad. Sci. U.S.A. 2006 22 64
    • Researchers have cloned YJR070C as the gene encoding deoxyhypusine hydroxylase and identified the human homolog deoxyhypusine hydroxylase gene, HLRC1.
  • Characterization of yeast deoxyhypusine synthase: PKC-dependent phosphorylation in vitro and functional domain identification. (PMID: 10630376,(ncbi.nlm.nih.gov)) Kang K.R. … Chung S.I. Exp. Mol. Med. 1999 22 64
    • DHPS mutations in yeast and E. coli were created to better understand the structure and function of DHPS. DHPS is phosphorylated by PKC in vitro but not by p56lck and p60c-src. DHPS is substrate for PKC dependent phosphorylation and requires most of the polypeptide chains for enzyme activity except the first 15 residues of N-terminal.
  • Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae. (PMID: 9430712,(ncbi.nlm.nih.gov)) Park M.H. … Kang K.R. J. Biol. Chem. 1998 22 64
    • Hypusine modification is necessary for the survival of S. cerevisiae and imply a vital function for eIF-5A in eukaryotes.
  • Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.(PMID: 9285100,(ncbi.nlm.nih.gov)) Liu Y.P. … Chen K.Y. Biol. Signals 1997 22 64
    • This study shows that eIF-5A can bind to RNA and that deoxyhypusine modification appears to be required for the binding. This suggests that deoxyhypusine formation of eIF-5A may be related to its role in RNA processing and protein synthesis.
  • Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine. (PMID: 1850732,(ncbi.nlm.nih.gov)) Park M.H. … Folk J.E. J. Biol. Chem. 1991 22 64
    • This study shows the importance of hypusine or deoxyhypusine for the biological activity of eIF-4D and demonstrate the influence of both the length and chemical nature of its amino alkyl side chain.
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